The Peter Parker/ Mary-Jane relationship is one of the cornerstones of comic book couples. While they aren't the number one on the list (Clark and Lois, I mean, they had a tv show and everything), they are a heavy hitting #2.
However, as anyone who keeps up with continuity will tell you, MJ and Peter aren't together anymore. After Peter unmasks on live TV during the events of Civil War, the Kingpin puts a hit out on him. Aunt May gets shot, and in a last ditch effort to save her, he and MJ trade their marriage for May's life and public knowledge of Peter's identity to be wiped from the general consciousness.
It's sort of depressing when you think about it. Peter and MJ were a very good couple. They have been through thick and thin, and while they are very different people, they compliment each other very well.
I want to talk more about their coupledom, but I'm just pissed they ended it. Peter and MJ were so good together, and now Peter is out there trying to meet someone new. I now they felt it aged the character, but Peter is older. He needs to face the challenges of maturity and grow up. He doesn't have to be all broody or get all serious. Look at Wally West. He grew up and had his own kids. He now has to work with the challenge of being a superhero and a dad at the same time. I'd love to see Peter Parker do that.
Maybe he and MJ will get back together. I hope they do. The end of One Moment in Time is hard to read. It's a brand new day though, and anything can happen.